Welcome to the Xu Lab!

We seek to understand the fundamental mechanisms that generate biological complexity in higher organisms, with a specific focus on plants. Our core hypothesis is that this complexity arises not just from the number of genes, but from the intricate interplay of alternative splicing, post-translational modifications, and protein-protein interactions. Our long-term objective is to fully elucidate the contributions of these layers of regulation. To accomplish this, we combine cutting-edge genetics, molecular biology, transcriptomics, proteomics, and analytical chemistry. Our current research program is dedicated to dissecting the molecular control of alternative splicing, mapping the regulatory functions of O-GlcNAcylation and O-fucosylation, and defining the architecture and cellular interaction maps of organelles.

Our Mission

Our lab uses a combination of advanced genetic, engineering, and "omics" technologies (transcriptomics and proteomics) to create a comprehensive map, or "atlas," of plant cells. Our goal is to understand how plants sense and respond to nutrients. Specifically, we are developing new technologies to answer key questions: How do plants create biological complexity? What is the machinery behind alternative splicing, and how is it built? How do sugar molecules change gene expression and splicing? Our science is built on a foundation of diversity, equity, and a dedication to sharing our findings openly with the scientific community and the public.

XU LAB FUN

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